懂色一区二区三区久久久,成人高清无码视频,中文字幕只是让你摩擦一下,国产精品人人爽人人做Av片

加入收藏 | 設(shè)為首頁 | 聯(lián)系我們

產(chǎn)品搜索

產(chǎn)品分類

聯(lián)系我們

聯(lián)系人：蔣經(jīng)理
電話：4008750250
號碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com

產(chǎn)品展示 / PRODUCTS
藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73194ETV6-NTRK3/BaF3

ETV6-NTRK3/BaF3
名稱 ETV6-NTRK3/BaF3
型號 CBP73194
報價
特點(diǎn) ETV6-NTRK3/BaF3,母細(xì)胞：BaF3，凍存條件：90% FBS+10% DMSO
  • 詳細(xì)內(nèi)容


CBP73194

I. Introduction

Cell Line Name：

ETV6-NTRK3/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10% FBS+1 ug/ml puromycin

Mycoplasma Status:

Negative


II.Background
ETV6-NTRK3 gene fusion is the translocation of genetic material between the ETV6 gene located on the short arm (designated p) of chromosome 12 at position p13.2 (i.e. 12p13.2) and the NTRK3 gene located on the long arm (designated q) of chromosome 15 at position q25.3 (i.e. 15q25.3) to create the (12;15)(p13;q25) fusion gene, ETV6-NTRK3. This new gene consists of the 5' end of ETV6 fused to the 3' end of NTRK3. ETV6-NTRK3 therefore codes for an chimeric oncoprotein consisting of the helix-loop-helix (HLH) protein dimerization domain of the ETV6 protein fused to the tyrosine kinase (i.e. PTK) domain of the NTRK3 protein. The ETV6 gene codes for the transcription factor protein, ETV6, which suppresses the expression of, and thereby regulates, various genes that in mice are required for normal hematopoiesis as well as the development and maintenance of the vascular network. NTRK3 codes for Tropomyosin receptor kinase C a NT-3 growth factor receptor cell surface protein that when bound to its growth factor ligand, neurotrophin-3, becomes an active tyrosine kinase that phosphorylates tyrosine residues on, and thereby stimulates, signaling proteins that promote the growth, survival, and proliferation of their parent cells. The tyrosine kinase of the ETV6-NTRK3 fusion protein is dysfunctional in that it is continuously active in phophorylating tyrosine residues on, and thereby continuously stimulating, proteins that promote the growth, survival, and proliferation of their parent cells. In consequence, these cells take on malignant characteristics and are on the pathway of becoming cancerous. Indeed, the ETV6-NTRK3 fusion gene appears to be a critical driver of several types of cancers. It was originally identified in congenital fibrosarcoma and subsequently found in secretory breast cancer (also termed juvenile breast cancer), Mammary analogue secretory carcinoma of salivary glands (also termed MASC or MASCSG), congenital fibrosarcoma, congenital mesoblastic nephroma, rare cases of acute myelogenous leukemia, ALK-negative Inflammatory myofibroblastic tumour, and radiation-induced papillary thyroid carcinoma.

III. Representative Data

1. WB of  ETV6-NTRK3/BaF3 expression

CBP73194 WB.jpg

2. Anti-proliferation assay

CBP73194 fig.png

Figure 2. Anti-proliferation assay of two reference compounds on the ETV6-NTRK3/BaF3 Stable Cell Line



如果你對CBP73194ETV6-NTRK3/BaF3感興趣，想了解更詳細(xì)的產(chǎn)品信息，填寫下表直接與廠家聯(lián)系：


留言框

  • 產(chǎn)品：

  • 您的單位：

  • 您的姓名：

  • 聯(lián)系電話：

  • 常用郵箱：

  • 省份：

  • 詳細(xì)地址：

  • 補(bǔ)充說明：

  • 驗(yàn)證碼：

    請輸入計算結(jié)果（填寫阿拉伯?dāng)?shù)字），如：三加四=7

化工儀器網(wǎng)

推薦收藏該企業(yè)網(wǎng)站
91激情网| 久久一三四五六区| 日日摸日日踫夜夜爽无码| 中文字幕毛片| 美女黄色一区二区| 欧美zc0o人与善交| 亚洲一二三区在线观看| 国产精品高清在线| 久久老熟女| 亚洲视频在线观看免费第一| 国产精品国产三级国产aⅴ原创 | 久久久久久蜜桃视频全集免费观看| 干极品少妇逼 高清| 9A蜜桃久久久久久免费| 国产亚洲AV无码精品| 久久免费视频国产| 大学生一级一片全黄| 嫩草亚洲| 开远市| 日本香蕉视频久久| 国产精品6| 欧美亚洲日本99| 五月 丁香 综合五月| 欧美日韩激情| 日韩毛片基地| 人妻综合 第一页| 久久精品午夜| 欧美黄片手机在线免费看| 女同av在线电影| 久久久蜜桃热女| 国产精品一区二区AV麻豆| 国产精品无码伦在线观看免费| 欧洲中文字幕V| 亚洲无玛人妻| 色综合久久成人综合网| 91久久不卡一卡| 国内精品自产拍在线观看| www.插插插.com| 欧美精品在线| 人妻不卡| 欧美熟妇精品一区二区三区免费|