名稱 | LAG3/HEK293 |
型號 | CBP74051 |
報(bào)價(jià) | |
特點(diǎn) | LAG3/HEK293,凍存條件:90% FBS+10% DMSO; |
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電話:4008750250
號碼:
手機(jī):18066071954
地址:南京市棲霞區(qū)緯地路9號
Email: zhangxiangwen@cobioer.com
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藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74051LAG3/HEK293
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LAG3/HEK293
CBP74051 | |
I. Background | |
Lymphocyte-activation gene 3 (LAG3, CD223) is a cell surface protein that belongs to immunoglobulin (Ig) superfamily. LAG3 is expressed on activated T cells, natural killer cells, B cells, and plasmacytoid dendritic cells. Its main ligand is MHC class II, to which it binds with higher affinity than CD4. It negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1, and has been reported to play a role in Treg suppressive function. A number of LAG3 antibodies are in preclinical development for treatments for cancer and autoimmune disorders. LAG3 may be a better immune checkpoint inhibitor target than CTLA-4 or PD-1 since antibodies to these two checkpoints are only activating effector T cells, and not inhibiting Treg activity where an antagonist LAG3 antibody can both activate effector T cells (by downregulating the LAG3 inhibiting signal) and inhibit induced (i.e. antigen-specific) Treg suppressive activity. | |
II. Description | |
Recombinant HEK293 stably expressing human LAG3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286). | |
III. Introduction | |
Host Cell: | HEK293 |
Expressed gene: | LAG3 |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Synonym(s): | LAG3, LAG-3, CD223 |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | DMEM +10%FBS+1ug/ml puromycin |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen. |
Application(s): | Binding Assay,FACS |
IV. Description of Host Cell Line | |
Organism: | Homo sapiens, human |
Tissue: | Embryonic kidney |
Disease: | Normal |
Morphology: | Epitheloid cell |
Growth Properties: | Adherent |
Ⅴ. Representative Data | |
Figure Recombinant HEK293 stably expressing human LAG3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286). |