名稱 | PVRIG(CD112R) Effector Reporter Cell |
型號 | CBP74120 |
報價 | |
特點 | PVRIG(CD112R) Effector Reporter Cell,凍存條件:90% FBS+10% DMSO; |
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藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74120PVRIG(CD112R) Effector Reporter Cell
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I. Background | |
PVRIG(CD112R),是脊髓灰質(zhì)炎病毒受體(PVR)家族的共抑制受體,在自然殺傷細(xì) 胞(NK)和 T 細(xì)胞上表達(dá)。它與其配體(CD112 或 PVRL2/nectin-2)結(jié)合,抑制 T 細(xì)胞和 NK 細(xì)胞對癌癥的反應(yīng)。因此,CD112R 作為一種新的免疫檢查點抑制劑在癌癥中 具有很高的潛力。 | |
II. Description | |
PVRIG(CD112R) Effector Reporter Cell 報告基因藥靶模型很好的模擬了體內(nèi) PVRIG 的 信號轉(zhuǎn)導(dǎo)過程,原理見下圖所示。 Figure 1. PVRIG(CD112R) Effector Reporter Cell | |
III. Introduction | |
Expressed gene: | PVRIG(CD112R) |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Synonym(s): | Poliovirus Receptor-related Immunoglobulin Domain-containing Protein, Transmembrane Protein PVRIG, 79270-1, 79270-2 |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | RPMI-1640+10%FBS+800μg/ml hygromycin+1μg/ml puromycin |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen |
Application(s): | Functional(Report Gene) Assay |
IV. Representative Data | |
Figure 2. Recombinant PVRIG(CD112R) Effector Reporter Cell stably expressing PVRIG(CD112R). | |
Figure 3. Dose Response of PVRIG Blocking Antibody in PVRIG(CD112R) Effector Reporter Cell (C7) With CD112/TCR Activator - CHO Cells. |